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Download Activation to Acquisition: Functional Aspects of the Basal by Russell T. Richardson (auth.), Russell T. Richardson (eds.) PDF

By Russell T. Richardson (auth.), Russell T. Richardson (eds.)

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Extra resources for Activation to Acquisition: Functional Aspects of the Basal Forebrain Cholinergic System

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Dev. Neurosci. 3:229-243 Beccari, N. (1911): La sostanza perforata anteriore e i suoi rapporti col rinencefalo mel cervello dell'uomo. Arch. Ita/. Anat. Embriol. S. A. (1982): Cholinergic excitation of mammalian hippocampal pyramidal cells. Brain Res. -A. and Mallet, J. (1987): eDNA cloning and complete sequence of porcine choline acetyltransferase: in vitro translation of the corresponding RNA yields an active protein. Proc. Nat/. Acad. Sci. USA 84:9280-9284 Bialowas, J. and Frotscher, M. (1987): Choline acetyltransferase-immunoreactive neurons and terminals in the rat septal complex: a combined light and electron microscopic study.

Growdon, J. , eds. , Arendt, A. and Tennstedt, A. (1983): Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans, and Korsakoff's disease. Acta Neuropathol. G. A. (1986): Dendritic changes in the basal nucleus of Meynert and in the diagonal band nucleus in Alzheimer's disease a quantitative Golgi investigation. Neurosci. 19:1265-1278 Ashton, H. (1987): Brain Systems, Disorders, and Psychotropic Drugs. , Shaver, R. and Bartus, R. (1984): Physiology of cortically projecting neurons in monkey nucleus basalis of Meynert.

1981, 1982). , 1988), emphasis is placed on cell shrinkage and dysfunction rather than on cell loss. , 1986). The major pathological changes in neurons of the NBM in AD and other dementias include: reductions in cell size and transmitter markers; cytoskeletal abnormalities; appearance of abnormal proteins in cells; participation of axons/terminals of these cells in neurite formation; and cell degeneration (Koo and Price, in press). The cholinergic hypothesis of AD has also received support from basic animal research showing that acetylcholine plays a major role in normal memory (Deutsch, 1971) as well as from clinical studies in human subjects showing that cholinergic synapse blockers produce amnesia in normal individuals (Drachman and Leavitt, 1974).

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