By Edward S. Meek M D, Ch B, MRC Path (auth.)
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Those of porfiromycin include leukopenia and thrombocytopenia. Mitomycin can also be considered as an antiviral agent. ODA (1963) reported suppression of the growth of vaccinia, but felt that this might result from inhibition of penetration of the cell by the virions. lg/ml, however, the penetration of poliovirus into cells was not interfered with; but at these concentrations the growth of Mengo encephalomyelitis virus was not suppressed (REICH and FRANKLIN, 1961). , 1961). Mycoplasma SOMERSON and COOK (1965) found that the growth of Rous sarcoma virus was suppressed in vitro by the presence of Mycoplasma orale in the culture.
However, in spite of their responses, there did not seem to be any distinct evidence of increase in survival, and the duration of remission was briefaveraging about 7 weeks. Mitomycin C is usually given intravenously (KNOCK, 1967); toxic effects, which are often delayed, include anorexia, diarrhoea, dehydration, fever, depression of bone marrow activity and that of lymphoid tissue, damage of gastrointestinal epithelium, liver and kidney. Those of porfiromycin include leukopenia and thrombocytopenia.
A recent study of the antimitotic effect of an extract has been published by CERIOTTI (1967); antimitotic substances are found in the bulbs of several varieties of narcissus. In an extensive screening programme, CUTTING and his colleagues (1965) found that six out of 130 Chinese herbs yielded aqueous extracts which showed activity in vivo against Col-SK virus infection in mice. Twenty-four extracts inhibited the growth of vaccinia in vitro, and one only was active against lymphocytic choriomeningitis virus in vitro.